Mesothelioma: VS-5584 Received Orphan Drug Designation

Verastem. Inc, a pharmaceutical company focused on the discovery and development of drugs directed against cancer stem cells, recently announced that VS-5584, oral inhibitor of focal adhesion kinase (FAK), has received orphan drug designation from the US Food and Drug Administration, for use in the treatment of mesothelioma.

It is an important regulatory milestone for Verastem that will facilitate the global development of the VS-5584, and that will help improve the treatment options available for patients suffering from this type of very aggressive cancer, said Robert Forrester, President Verastem.

Verastem has recently initiated a Phase 1 clinical study in order to evaluate the synergistic activity in combination with VS-5584 VS-6063, in patients with progressive or relapsed malignant pleural mesothelioma.

Moreover VS-5584 is subjected to a phase 1 further study to evaluate the use against advanced solid tumors, such as mesothelioma, in patients who have previously shown good tolerance to the drug.

Comments

General Information about Malignant Mesothelioma

Malignant mesothelioma is a disease in which malignant (cancerous) cells form in the lining of the chest or abdomen. Malignant mesothelioma is a disease in which malignant (cancer) cells are found in the pleura (the thin layer of tissue that lines the chest cavity and covers the lungs) or the peritoneum (the thin layer of tissue that lines the abdomen and covers most of the organs of the abdomen). Malignant mesothelioma can form in the heart or testicles, but this is not common Exposure to asbestos can influence the risk of malignant mesothelioma. Anything that increases the risk of getting a disease is called a risk factor. Having a risk factor does not mean you are going to have cancer; Having no risk factors does not mean you will not have cancer. Talk to your doctor if you think you may be at risk. Most people with malignant mesothelioma have worked or lived in places where they inhaled or swallowed asbestos. After exposure to asbestos, it usually takes a lon...

Clinical-Radiological Markers of Exposure to Asbestos

There is some confusion about the criteria for exposure to asbestos. In the accreditation of the asbestos exposure there are 3 criteria that in order of importance are: 1.- the work history 2.- the exposure markers. 3.- The detection of asbestos bodies in biological samples. When there is a clear history of exposure to asbestos, as is the work activity in the different industrial sectors in which asbestos has been present, exposure to asbestos is sufficiently proven. The second criterion in importance is the existence of exposure markers. In this sense, clinical-radiological markers such as pleural plaques, diffuse pleural fibrosis and round atelectasis guarantee exposure to asbestos in a high proportion of cases, which reaches 81% -89% in round atelectasis (1). Finally, and contrary to what might appear, the negativity in the detection of asbestos bodies in biological samples does not exclude exposure to asbestos when one of the 2 major criteria is present: the work history and / or ...

Legal Options After A diagnosis of Mesothelioma

If your doctor diagnosed you or a loved one with mesothelioma, it is important to follow their recommendations to the letter. It is also advisable to receive legal advice from an experienced lawyer, since you could receive compensation for medical expenses, treatments, pain, suffering and lost wages. If you decide to seek legal help, there are three very important questions that a lawyer will ask you: Were you or your loved one exposed to asbestos or asbestos? Where and when did this exposure to asbestos occur? What damage did the person suffer as a result of exposure to asbestos? Exposure to asbestos at work If the asbestos exposure occurred at work, you could file a lawsuit against your employer. If you worked in the following industries, it is very likely that you were exposed to asbestos: Building Factories / manufacturing Firefighters Naval building ...

Mesothelioma Pathology Outlines

Search This Blog