Skip to main content

Mesothelioma, In the US a new Orphan Drug for the Treatment of Neoplasia

It is BAY 94-9343, an experimental anticancer agent

A new orphan drug for the treatment of mesothelioma. It is BAY 94-9343, an experimental anticancer agent produced by Bayer HealthCare, which has obtained the status of an orphan drug by the Food and Drug Administration. It is an experimental drug currently in clinical development.

The drug is an ADC (in drug conjugated antibodies) that combines the targeting properties of an antibody with the effect cellular destruction of a small and powerful molecule of the cytotoxic agent.

BAY 94-9343 (mesothelin-ADC) is an antibody-conjugated drug that targets mesothelin, molecule highly expressed in mesothelioma. It is a drug that ultilzza an entity fully human antibody, generated thanks to the technology of HuCAL Morphos Platform.

The drug has been shown to have a powerful and targeted anti-cancer activity in preclinical studies.

In September 2011 it has started patient enrollment for a Phase I open-label to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of the drug. Patients are currently treated with BAY 94-9343 at three research centers in the United States (Maryland, Tennessee and Texas). For more information on this study (NCT01439152), you can visit the website www.clinicaltrials.gov.

"This is an important step in the development process of this investigational drug," said Prof. Andreas Busch, member of the Bayer HealthCare Executive Committee and Head of Global Drug Discovery. "Malignant mesothelioma is a rare type of cancer with a poor prognosis. C 'is a significant unmet medical need for these patients. Bayer therefore undertook to develop a therapy that can help people with this cancer to live longer longer, improving the quality of their lives. "

Recall that mesothelioma is a rare tumor, which represents less than 1 percent of all cancers. It develops from the cells of the mesothelium, the thin protective membrane that surrounds the large serous cavities of the human body. Malignant pleural mesothelioma is the most common form of mesothelioma.
Labels:

Comments

Post a Comment

Popular posts from this blog

General Information about Malignant Mesothelioma

Malignant mesothelioma is a disease in which malignant (cancerous) cells form in the lining of the chest or abdomen. Malignant mesothelioma is a disease in which malignant (cancer) cells are found in the pleura (the thin layer of tissue that lines the chest cavity and covers the lungs) or the peritoneum (the thin layer of tissue that lines the abdomen and covers most of the organs of the abdomen). Malignant mesothelioma can form in the heart or testicles, but this is not common Exposure to asbestos can influence the risk of malignant mesothelioma. Anything that increases the risk of getting a disease is called a risk factor. Having a risk factor does not mean you are going to have cancer; Having no risk factors does not mean you will not have cancer. Talk to your doctor if you think you may be at risk. Most people with malignant mesothelioma have worked or lived in places where they inhaled or swallowed asbestos. After exposure to asbestos, it usually takes a lon...
1 comment
Read more

Legal Options After A diagnosis of Mesothelioma

If your doctor diagnosed you or a loved one with mesothelioma, it is important to follow their recommendations to the letter. It is also advisable to receive legal advice from an experienced lawyer, since you could receive compensation for medical expenses, treatments, pain, suffering and lost wages. If you decide to seek legal help, there are three very important questions that a lawyer will ask you: Were you or your loved one exposed to asbestos or asbestos? Where and when did this exposure to asbestos occur? What damage did the person suffer as a result of exposure to asbestos? Exposure to asbestos at work If the asbestos exposure occurred at work, you could file a lawsuit against your employer. If you worked in the following industries, it is very likely that you were exposed to asbestos:      Building      Factories / manufacturing      Firefighters      Naval building  ...
Post a Comment
Read more

Mesothelioma, Treatments Are More Effective Thanks To Grape Seeds

In Italy it represents 0.4% of all malignancies diagnosed in men and 0.2% of those diagnosed in women. The study was born from the collaboration between ENEA, CNR and the "Federico II" University of Naples Mesothelioma is a tumor that arises from the cells that line the mesothelium. It is a fabric that covers the surface of the serous membranes which, in turn, line the inner wall of the chest, abdomen and space around the heart. Depending on the affected area, the mesothelium takes on different names. The main risk factor for this disease is exposure to asbestos.  This term indicates a family of minerals rather common in nature with a fibrous structure very resistant to heat. Its fibers, if inhaled, settle in the lungs and can damage the mesothelial cells causing, in some cases, pleural cancer. Other less common risk factors are exposure to zeolites with erionitis, radiation to the chest and abdomen, thorium injections (used in medicine until 1950).  According ...
Post a Comment
Read more